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Short-acting (eg, triazolam) and intermediate-acting (eg, estazolam, temazepam) benzodiazepine receptor agonists are useful for sleep-onset insomnia.
These agents have been the hypnotics of choice for many years because of their relative safety compared with the barbiturates, as well as their low cost.
Nevertheless, certain barbiturates are still employed as anticonvulsants (phenobarbital) and to induce anesthesia (thiopental).
The representatives of this group are: Benzodiazepines are the most widely used group of sedative drugs.
Each type (class) of antidepressant affects these neurotransmitters in slightly different ways.
Besides those two groups of drugs, other sedatives are also used for that purpose.
When prescribing an antidepressant that's likely to work well for you, your doctor may consider: Certain brain chemicals called neurotransmitters are associated with depression — particularly serotonin (ser-o-TOE-nin), norepinephrine (nor-ep-ih-NEF-rin) and dopamine (DOE-puh-meen).
Most antidepressants relieve depression by affecting these neurotransmitters.
By binding to specific subunits of GABA Benzodiazepines are on the Beer’s List of potentially inappropriate medications for older patients.
They are not recommended in the elderly because of the risk of falls; if used, they should be given at the lowest effective dose for the shortest amount of time.
Although sedatives do not relieve pain in themselves, they can be a useful adjunct to analgesics in preparing patients for surgery, and are commonly given to patients before they are anaesthetized, or before other highly uncomfortable and invasive procedures like cardiac catheterization, colonoscopy or MRI.